Turan MT, Esel E, Dundar M,
Candemir Z, Basturk M, Sofuoglu S, Ozkul Y.
Department of Psychiatry, Erciyes University
School of Medicine, Kayseri, Turkey.
Abstract [Full Text] [PDF]
There are few reports describing chromosomal
abnormalities in transsexuals. In rare cases, transsexualism and sexual
chromosomal multiplicity coexist. Six cases of male-to-female transsexuals
with 47,XYY chromosomal pattern have been previously reported. We have not
encountered any female transsexual cases with 47,XXX karyotype in the
literature.
Methods A 21-year-old female patient came
to our outpatient department with depressive symptoms and suicidal thoughts.
On psychiatric interview, she reported that she had feelings of discomfort
with her gender identity and had desired to be male since her childhood.
Then, we performed cytogenetic investigation using blood culture and G
chromosome banding.
Results Histology and DNA histograms of the
patient revealed a chromosomal pattern of 47,XXX.
Conclusions We conclude that sexual
chromosomal abnormalities in some transsexuals may cause a vulnerability to
development of a gender identity disorder.
Citation:
Biol Psychiatry 2000 Dec 1;48(11):1116-7 an article published on the
Internet by PubMed <http://www.ncbi.nlm.nih.gov/>
